Example Abstracts


The Sciences



Twyno-Targeted Molecular Delivery and Carrier Methods of Cytotoxic Chemotherapeutic Agents

Rebecca Blass & S. Jenny Van

Molecular delivery and carrier methods are among the most recent advancements in the field of oncology to reduce toxic side effects and prevent multidrug resistance seen in traditional chemotherapy regimens. Chemotherapy agents are cytotoxic agents that often cannot be administered at the high dosage level needed to halt metastatic groth due to their cytotoxic effect on normal tissue as well as the neoplastic tissue. Novel cytotoxic agents that can be targeted to the neoplastic site of interest include prodrugs and immunotoxins, and will be included, and will be included in the discussion of targeting chemotherapeutic agents. Delivery methods of targeting cytotoxic agents to specific malignant sites include conjugation with tumor-specific monoclonal antibodies, antibody-directed enzyme prodrug therapy (ADEPT), gene-directed enzyme prodrug therapy site, all of which involve a site-specific method of targeting the cytotoxic agent. Carrier methods for delivering cytotoxic agents to malignant sites include second-generation liposomes and water-soluble polymers, both of which reduce drug uptake at normal tissues and reduce toxic side effects. The result of the advancement of these regimen and the combination of targeting methods is a higher delivered dose of traditional chemotherapy treatments with an improved efficacy of tumor regression, less systemic toxicity, and reduced multidrug resistance.


Generalizing Hyperlink-Based Analysis for Improved Contextual Searches

Daniel Haspel, Gabriel Robins, Brian Street

This paper describes a generalized method for finding relevant web pages based on their context, where context in this sense is defined by the localized hyperlinks to and from each page. The proposed method handles a large class of information retrieval operations, including automatic taxonomy generation, web searching, and related-page searching, as well as a broad family of previously unaddressed tasks. This is possible through the use of a new measure of authority that exploits the link structure among the selected pages. In addition, we show that our method directly generalizes Kleinberg's "HITS" algorithm and Dean and Henzinger's related-page finding algorithm. We provide three specific implementations using our method: (1) a topic-specific web search allowing user refinement of results, (2) a mechanism for developing a list of pages "interesting" to a user, and (3) a tool that finds specific consumer products based on very general query terms.


Anastomosis and Doppler Flow Meter Coupling Device for Skin Grafts

Margaret Kramer

When skin graft or flap procedures are performed, the blood vessels from the graft or flap must be connected to the vessels leading from the location of attachment on the patient. This process of joining vessels is known as anastomosis. In the postoperative period following surgery it is not uncommon for a graft to fail because the method of monitoring blood flow to the new graft is notably unreliable. I have designed a device that can be attached to an existing surgical apparatus used in anastomosis. This device allows Doppler ultrasound imaging to monitor blood flow more accurately so that physicians can intervene if a clot develops and blood flow is reduced.


Design and Synthesis of a Novel Caprolactam

Victoria K. Landry

A new five-member ring a-hydroxy-a-phenelcaprolactam, a ring contracted derivative of the previously synthesized seven-member a-hydroxy-a-phenelcaprolactam, has been designed (utilizing information drawn from computer medeling programs) and is being synthesized for testing as a selective, nontoxic anticonvulsant. The previously synthesized seven-member caprolactam derivative's efficacy in combatng seizure activity as well as biological evidence suggesting a five-member ring's activity motivates the direction of this synthesis, which remains in progress. This report contains background information on previous chemical and biological research, the synthetic scheme and experimentals for the seven-member caprolactam, several proposed but as yet unsuccessful total synthetic schemes for the target molecule, a summary of the methods successfully and unsuccessfully attempted, and a description of the computer modeling programs used in the project.


Transforming Electronically Encoded Music

Baron Schwartz

MEI (Music Encoding Initiative, pronounced bat uses XML syntax to store musical data. Musical data stored in MEI files can be retrieved and used to generate printed music notation. Because music notation requires storing a great deal of information about the music, it is possible that the format will be useful for other purposes such as analysis and cataloguing as well.


Humanities



The Eastern Answer: Recovering Organic Nationalism as a Tool for Understanding Non-Western Peoples

Dustin Wentz Batson

The Organic Theory of nationalism stands opposed to the Voluntarist model manifested in the French Enlightenment and accepted as the foundation for the modern bevertheless, many national groups are based not upon a political ideal but on a sense that ethnic kinship and history should naturally translate into political communities and sovereignty. To properly understand such peoples, it is necessary to reexamine the theory upon which they have built their nations.


SELEDRAMAS, WAȚEMA GEBIND, & FÆSTNUNG: Binding and Bonding in The Wanderer

Denis Ferhatovic

The aim of this paper is to explore the pervasive imagery of bonding and binding in the Old English poem The Wanderer. The essay points out the recurring paradox - the simultaneous protection and oppression of the diverse enclosures in the texts, be they mental, physical, societal, or literary. Finally, it sees the elegy itself as a kind of container that much like the speaker's "spirit-locker", takes in his restless thoughts.


Common Grounds Beyond the Noisy Throng: Hull House and the Chicago Greeks

Stephania Gianulis

At the turn of the twentieth century, urban growth flourished in Chicago; industrialization as expanding, and eastern European immigrants poured into the city seeking opportunity. In the midst of Americans whose jobs and growing capitalistic dream were threatened, a social reformer named Jane Addams founded the Hull House, a settlement house community, to welcome her new neighbors within a zone of enlightened ease. Addams had a particularly good relationship with the Greek immigrants, who thrived at Hull House. As they settled in Chicago, the Greeks established churches in order to retain a tradition of Hellenism and practice that kept them linked to their homeland. Retaining their ethnic and spiritual heritage was both a priority and a challenge; the ancient Greek Orthodox tradition of sacraments and ritual was conspicuous among the American Protestantism that predominated Chicago. To evangelical Christians, the Greeks were out of date and starving for rational faith. To Greeks, sacramental ritual was the most important element of faith, and had kept their Church alive for centuries. Jane Addams, who distinguished herself from the world-view of evangelism, sought a more "primitive" Christianity; in light of the most Orthodox Orthodoxy, she sought essentially what her Greek friends remembered. Her relationship with them ran deeper than the language barrier could allow. Not only did Addams offer the Greeks an opportunity to celebrate their heritage at Hull House; this humanist's deepest convictions about faith, community, and charity held common ground with the spiritual foundations of the Greek Orthodox faith.


Assessing Jihad: Understanding the Command to Struggle in Islam

Anna Levin

In an attempt to redefine a word frequently misused internationally, this paper examines Jihad from a historical, anthropological, and theological perspective. In whole, the piece attempts to reconcile the conflict between Islam's inherent dedication to justice, and the assertions that it motivates irrational warfare in the name of Holy War. Finally, the piece uses elements of Qu'ranic texts to assert interpretations that present a unique and positive perspective towards the current philosophical attempts to establish a universal ethic and codify natural law.


Southern Secession

Catherine Neale

The question of secession has plagued historians ever since South Carolinaber 20, 1860. Secession cannot be viewed as one mass exodus by the entire South, but as a series of well-thought departures by individual states. Virginiabcession of Tennessee or South Carolina. A culmination of events - including an increasing opposition to Lincoln and the "Black Republicans," a loss of majority in Congress, the secession of multiple states, a failed Peace Conference, and the growing power of the Confederacy - led to intensified sentiments of secession in Virginia. However, the final decision for Virginia to secede arrived on April 17, 1861, only after Virginians declared that their Constitutional rights had been violated.


Crossing the Line: Transgression of Socio-Economic Boundaries in Twelfth Night and The Duchess of Malfi

Kristen Patton

The author explores issues of gender and socio-economic distinction, particularly with regard to attempts to cross those boundaries through sexual encounters, in Shakespeare's Twelfth Night and Webster's The Duchess of Malfi. These plays, one a comedy the other a tragedy, demonstrate the role of erotic encounters between members of different classes in social promotion. Within both plays the element of gender role reversals plays a large part in heightening tension at the climax of each play.


Huracán

Elizabeth Whelan

In late October, 1998, Honduras suffered the brunt of Hurricane Mitch. The constant, heavy rains for over a week created severe flooding throughout the country that caused whole towns, neighborhoods, and crops to be washed away or covered with water and mud. Hurricane Mitch has been termed by many as the largest natural disaster ever to hit the Western Hemisphere.