Sciences: Genome Instiability
Department: Biochemistry and Molecular Genetics
Supervising Faculty Member: Anindya Dutta
Specialization: Genome instability in cancers and regulation of gene expression by noncoding RNAs
Research Focus: Cancer cells have unstable genomes. I study how this instability occurs and whether we can exploit this weakness for diagnosis and therapy. Gene expression defines how a cell behaves:
is it normal or malignant? Is it muscle cell or a brain cell? I study how non-protein coding RNAs regulate genes.
1) cell culture, transfections
2) protein or RNA or DNA extractions
3) Westerns, PCR,
4) Molecular biology: growing plasmids in bacteria
5) The student will be given a defined project that s/he has to complete
Required Skills/Knowledge: Experience in molecular biology. If someone is familiar with R, UNIX, C++, Python, I have some good bioinformatics projects. Second year students only.
Required Courses: Coursework in molecular /cell biology or in computer science.
Training: Biosafety and radiosafety training will be a plus. Second year student preferred.
What You Will Learn:
1) Learn how to read papers and formulate questions
2) Learn how to troubleshoot experimental problems and produce publishable data
3) Learn how to work hard and in a focused manner that either proves or disproves a hypothesis