Dr. Jerry Nadler and
Dr. Raghu Mirmira

Diabetes as the Next Healthcare Epidemic: Challenges and Solutions
April 28, 2006
Fairfax, VA

On the web

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LEAD Summer Business Institute
UVa participates in the national LEAD Summer Business Institute (SBI)--a rigorous three week program that introduces academically-gifted minority high school juniors to the principles of business leadership.

Online Business Lectures: Leading in Turbulent Times
Leading in Turbulent Times lecture series by UVa Darden faculty is available online.

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On the shelf

Jerry Nadler:

Wen Y, Gu J, Thomas L, Gonzales N, Knaus UG and Nadler JL: Evidence that 12-lipoxygenase products activate the p21-activated kinase. Biochem J 349, 481-487. 2000.

Wen Y, Gu J, Liu Y, Wang P, Sun Y, and Nadler JL: Overexpression of 12-Lipoxygenase causes cardiac fibroblast cell growth. Circulation Res. 88:70-76. 2001.

Kim PM, Natarajan R, Dooley AN , Hernandez F, Gu J-L, Berliner JA, Nadler JL, and Hedrick CC: Adenoviral delivery of a leukocyte-type 12 lipoxygenase ribozyme inhibits effects of glucose and PDGF in vascular wall cells. Circ Res. Apr 13;88(7):659-65. 2001.

Raghu Mirmira:

Iype, T, Ziesmann, S.M., Taylor , D.G., Garmey, J.C., and Mirmira, R.G. (2004). The Transcriptional Repressor Nkx6.1 Also Functions as a DNA Context-Dependent Transcriptional Activator During Pancreatic b cell Differentiation: Evidence for Feedback activation of the nkx6.1 Gene by Nkx6.1. Mol. Endocrinol. 18, 1363-1375

Gasa, R, Mrejen, C, Leachman, N, Otten, M, Barnes, M, Chakrabarti, S, Mirmira, R, and German, M (2004). An In Vitro Model of Pancreatic Islet Cell Differentiation Driven by Proendocrine Genes. Proc. Natl. Acad. Sci. U.S.A 101, 13245-13250.

Chakrabarti, S.K., Francis, J., Ziesmann, S.M., Garmey, J.C., and Mirmira, R.G. (2003). Covalent Histone Modifications Underlie the Developmental Regulation of Insulin Gene Transcription in Pancreatic b Cells. J. Biol. Chem. 278, 23617-23623

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About the speakers

Dr. Nadler  has made important contributions to understanding the pathways associated with cardiovascular disease. Dr. Nadler has over 100 peer-reviewed publications. In 2001, Dr. Nadler was selected as the Co-Chairman for the National Institute of Health (NIH) Diabetes Center review committee. He has also serves on a special advisory committee to the Director of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) and is on the Program Committee for the ADA National Scientific Sessions.
 
Dr. Raghu Mirmira has a Ph.D. (in Biochemistry) and MD degree from the University of Chicago.  He did his postdoctoral training in the laboratory of Dr. Michael German at the University of California, San Francisco. His lab is studying the specific transcription factors, the timing of their expression, their target genes and their structural properties in developing islet cells.  Dr. Mirmira won the Thomas R. Lee Career Development Award from the American Diabetes Association to investigate how insulin-producing cells form.

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