Engineering faculty named AIMBE fellows
American Institute of Medicine and Biomedical
Engineering has elected Klaus Ley and Thomas C. Skalak as
fellows. Both are U.Va. professors of biomedical engineering.
institute recognized Ley for his outstanding contributions to
the study of the mechanics of adhesion molecules and their role
in inflammation and atherosclerosis. The institute cited Skalak
for his work on microvascular mechanics, vascular adaptation and
mathematical modeling of the microcirculatory networks.
Ley and Tom Skalak have been instrumental in making the Department
of Biomedical Engineering one of the best in the nation,"
said Richard Miksad, dean of the School
of Engineering and Applied Science. "They are both tireless
researchers and inspiring teachers."
research focuses on the role of selectins, an adhesion molecule
involved in the recruitment of cells from the blood stream, as
part of the inflammation process. A medical doctor, he holds a
joint appointment with U.Va.'s Department of Molecular Physiology
and Biological Physics. Ley has studied the differences between
the three types of selectins and their role in leukocyte, or white
blood cell, selection during inflammation. Two other research
projects include: the role of selectins and other adhesion molecules
in the development of atherosclerosis, or hardening of the arteries,
and the role of selectin and integrin, another adhesion molecule,
in the spread of cancer.
work centers on microvascular network remodeling. The microvessel
network is critical to cardiovascular health, delivering oxygen
and nutrients and removing metabolic waste. This highly adaptable
system can remodel itself in response to mechanical and biochemical
stimuli. A central thrust of Skalak's research is understanding
vascular adaptation to environmental conditions and vascular diseases.
He is interested in remodeling as a function of mechanical stresses,
vascular pattern formation and engineering of wound prevention
principal activities include participation in the formulation
of public policy; the dissemination of information, both to the
public and scientific community, through publications and forums;
For more information, see the Biomedical Engineering Web site