Drug combination knocks out
U.Va. scientists have developed a new combination drug therapy
that delivers a one-two punch to knock out colds. In study results
reported in the online issue of The Journal of Infectious Diseases,
a new combination of drugs stopped patients viral infection
and reduced symptoms by as much as 73 percent with no serious
studys lead author is Dr. Jack M. Gwaltney Jr., who chairs
the Division of Epidemiology and Virology in the Department
of Internal Medicine. Co-investigators were U.Va. colleagues
Dr. J. Owen Hendley and Dr. Birgit Winther.
ingredient of the treatment is the antiviral drug interferon,
which attacks the virus infection itself and makes cells resistant
to cold virus infection for up to 24 hours. The other two treatment
ingredients treat the inflammatory pathways that cause cold symptom.
Chlorpheniramine is an antihistamine and anticholinergic, which
blocks sneezing and runny nose. Ibuprofen reduces sore throat,
coughing and headache. Treatment with these drugs also reduces
researchers tested the treatment in a double blind, placebo-controlled
clinical trial in 150 young male and female adults. During the
five days of the study, the daily average total symptoms score
of volunteers receiving the actual drugs were reduced by 33 percent
to 73 percent compared to those on placebo treatment. Volunteers
who received the drugs experienced reduced severity of sneezing,
runny nose, nasal obstruction, sore throat, cough and headache.
They also had less nasal mucus production, nasal tissue use and
virus concentration in nasal secretions.