David Kashatus Laboratory
Kendall Lab UVA

Publications

Publications:

Kashatus DF, Restraining the Divider: A Drp1-Phospholipid Interaction Inhibits Drp1 Activity and Shifts the Balance from Mitochondrial Fission to Fusion.  Mol. Cell., 63(6): 913-5 (2016).

Nascimento A, Lannigan J, and Kashatus DF, High-Throughput detection and quantification of mitochondrial fusion through Imaging Flow Cytometry, Cytometry, 89: 708–719 (2016).

Kashatus DF, The many roles of Ral GTPases in Ras-driven cancer, In: Azmi, A, editor.  Conquering Ras: From Biology to Therapy; Elsevier Academic Press; (2016).

Xie Q, Wu Q, Horbinski C, Flavahan WA, Yang K, Zhou W, Dombrowski S, Huang Z, Fang X, Ferguson AN, Kashatus DF, Bao S, and Rich JN, Mitochondrial Control by DRP1 in Brain Tumor Initiating Cells, Nat. Neurosci., 18(4): 501-510 (2015).

Kashatus JA*, Nascimento A*, Myers LJ, Sher A, Byrne FL, Hoehn KL, Counter CM, and Kashatus DF, Erk2 phosphorylation of Drp1 promotes mitochondrial fission and MAPK-driven tumor growth, Mol. Cell, 57: 537–551 (2015). (*co-first authors).

Kashatus DF, An in vitro system to evaluate the scaffold function of the RalA effector protein RalBP1, In: Trabalzini, L & Retta, S, editors.  Methods in Molecular Biology: vol. 1120, Ras Signaling; Humana Press (2014).

Kashatus DF, Ral GTPases in tumorigenesis: emerging from the shadows, Exp. Cell Res., 319(15): 2337-42 (2013).

Lampson BL, Kendall SD, Ancrile BB, Morrison MM, Shealy MJ, Barrientos KS, Crowe MS, Kashatus DF, White RR, Gurley SB, Cardona DM and Counter CM, Targeting eNOS in Pancreatic Cancer, Cancer Res., 72: 4472-82 (2012).

Kashatus DF and Counter CM, Breaking up is hard to do: RalA, mitochondrial fission and cancer, Small GTPases, 2(6): 329-333 (2011).

Kashatus DF, Lim K-H, Brady DC, Pershing NLK, Cox AD and Counter CM, RalA and RalBP1 regulate mitochondrial fission at mitosis, Nature Cell Biology, 13(9): 1108-15 (2011).

Zipfel PA, Brady DC, Kashatus DF, Ancrile BB, Tyler DS, and Counter CM, Ral activation promotes melanomagenesis, Oncogene, 29(34): 4859–64 (2010). 

Vignola M, Kashatus D, Taylor G, Counter CM, and Valdivia RH, cPLA2 regulates the expression of Type I interferons and intracellular immunity to Chlamydia trachomatis, Journal of Biological Chemistry, 285(28): 21625-35 (2010).

Kashatus DF and Counter CM, A role for eNOS in oncogenic Ras-driven cancer. In: Bonavida B, editor. Nitric Oxide and Cancer; Prognosis, Prevention, and Therapy. New York: Springer, (2010).

Lim K-H, Brady DC, Kashatus DF, Ancrile BB, Der CJ, Cox AD, and Counter CM, Aurora-A phosphorylates, activates and relocalizes RalA, Molecular and Cellular Biology, 30(2): 508-23 (2010). 

Lim K-H*, Ancrile BB*, Kashatus DF*, and Counter CM, Tumour maintenance is mediated by eNOS, Nature, 452(7187): 646-9 (2008). (*co-first authors).

Kashatus D, Cogswell P and Baldwin AS Jr., Expression of the Bcl-3 proto-oncogene suppresses p53 activation, Genes and Development, 20(2): 225-35 (2006). 

O’Neil B, Buzcova P, Farrah H, Kashatus D, Sanoff H, Goldberg RM, Baldwin AS Jr. and Funkhouser WK, Expression of NF-κB family proteins in hepatocellular carcinomas, Oncology, 72(1-2): 97-104 (2007).

Kashatus D, Cogswell P and Baldwin AS Jr., Expression of the Bcl-3 proto-oncogene suppresses p53 activation, Genes Dev., 20(2): 225-35 (2006).

Hanson JL, Hawke NA, Kashatus DF and Baldwin AS Jr., The nuclear factor kappaB subunits RelA/p65 and c-Rel potentiate but are not required for Ras-induced cellular transformation, Cancer Res., 64(20): 7248-55 (2004).

Cogswell PC, Kashatus DF, Keifer JA, Guttridge DC, Reuther JY, Bristow C, Roy S, Nicholson DW and Baldwin AS Jr., NF-κB and IκBα are found in the mitochondria. Evidence for regulation of mitochondrial gene expression by NF-κB, J. Biol. Chem., 278(5): 2963-8 (2003).

Reuther-Madrid JY, Kashatus DF, Chen S, Li X, Westwick J, Davis RJ, Earp HS, Wang CY and Baldwin AS Jr., The p65/RelA subunit of NF-κB suppresses the sustained, antiapoptotic activity of Jun kinase induced by tumor necrosis factor, Mol. Cell Biol., 22(23): 8175-83 (2002).

Pubmed Listings for David Kashatus, Ph.D. http://www.ncbi.nlm.nih.gov/pubmed?term=Kashatus+D[Author]