Institute of Medicine and Biomedical Engineering Names Two U.Va.
Engineering Faculty Members as Fellows
March 14, 2001--
The American Institute of Medicine and Biomedical Engineering has
elected two University of Virginia professors as fellows. They are
Klaus Ley (right), and Thomas C. Skalak (mouse over image), both
professors of biomedical engineering.
institute recognized Ley for his outstanding contributions to the
study of the mechanics of adhesion molecules and their role in inflammation
and atherosclerosis. The institute cited Skalak for his work on
microvascular mechanics, vascular adaptation, and mathematical modeling
of the microcirculatory networks.
Ley and Tom Skalak have been instrumental in making the Department
of Biomedical Engineering one of the best in the nation," says
Richard Miksad, dean of U.Va.'s School
of Engineering and Applied Science. "They are both tireless
researchers and inspiring teachers."
research focuses on the role of selectins, an adhesion molecule
involved in the recruitment of cells from the blood stream, part
of the inflammation process. He has studied the differences between
the three types of selectins and their role in leukocyte, or white
blood cell, selection during inflammation. He also is interested
in understanding the role of selectins and other adhesion molecules
in the development of atherosclerosis, or hardening of the arteries.
He also is researching the role of selectin and integrin, another
adhesion molecule, in metastasis, or the spread of cancer cells
by adhering to tissue throughout the body.
work centers on microvascular network remodeling. The microvessel
network is critical to cardiovascular health, delivering oxygen
and nutrients and removing metabolic waste. This highly adaptable
system can remodel itself in response to mechanical and biochemical
stimuli. A central thrust of Skalak's research is understanding
vascular adaptation to environmental conditions and vascular diseases.
He is interested in remodeling as a function of mechanical stresses,
vascular pattern formation, and engineering of wound prevention
Ley and Skalak have published widely. Ley has produced more than
100 articles in peer-reviewed journals and 13 book chapters. He
edited "Physiology of Inflammation," a comprehensive text on the
mechanisms of inflammation. A medical doctor, he holds a joint appointment
with U.Va.'s Department of Molecular Physiology and Biological Physics.
has produced more than 60 publications, five book chapters, and
one book, "Microvascular Mechanics," with J. S. Lee. He has organized
and chaired numerous scientific sessions and was president of the
Biomedical Engineering Society in 2000.
more information on the work of these professors, see the Biomedical
Engineering Website (http://www.med.virginia.edu/bme/faculty.html.)
Fariss Samarrai, (804) 924-3778