RELEASE ON RECEIPT U.VA. BOARD EARMARKS $5.3 MILLION IN PRIVATE FUNDS FOR UNUSUALLY PROMISING RESEARCH AND TEACHING PROGRAMS CHARLOTTESVILLE, Va., June 9 -- The University of Virginia's Board of Visitors today selected 10 unusually promising U.Va. research-and-teaching programs to receive more than $5.3 million in private funds over the next three years to support further advances in their fields. The winning proposals for Academic Enhancement Program (AEP) grants were selected from more than 70 projects proposed since the board approved renewal of the program a year ago. The grants, the second set awarded since the board began the innovative program in 1989, are aimed at enhancing the national status of already distinguished programs. The 10 projects selected promote links between teaching, technology and research and are expected to contribute to economic development by attracting substantial outside funding. Projects in the initial group, in which the University invested a total of $10 million over a five-year period, attracted an additional $20 million in outside support. Together these funds created 200 new jobs, said Gene D. Block, vice provost for research at U.Va. Three of the newly funded projects focus on environmental issues, three involve physics, and the remaining four are in the areas of radiology, molecular physiology, biology and humanities. Principal investigators of the research groups include: Brian R. Duling, Robert M. Berne Professor of Cardiovascular Research, will receive $457,041 over three years to expand the expertise of faculty in molecular genetics and gene regulation. "The ultimate aim of our work is to extend basic research in gene transfer to gene therapies for the treatment of cardiovascular diseases," says Duling. Duling's group plans to develop tissue-specific promoters (which turn genes 'on' and 'off'), reporter molecules (which signal altered gene function), and a mouse physiology laboratory, where scientists can observe the results of gene manipulation in experimental animals. James R. Brookeman, professor of radiology and biomedical engineering, was awarded $409,032 to be used over three years in a program for advanced medical imaging technology. "The rapid integration of computers into the health care environment and the impetus for the nationwide development of computerized medical records means that imaging scientists must develop novel methods for acquiring, manipulating, archiving, and displaying images," says Brookeman. The development and integration of these new technologies into the health care setting present an attractive opportunity for cooperation between medical professionals and engineers and for mutually beneficial corporate-academic partnerships, he adds. Steve A. Kay, assistant professor of biology, will use $696,629 in AEP monies to develop an Advanced Cellular Imaging Facility at U.Va. "Progress in cutting-edge biomedical studies has become increasingly dependent upon the technology required to measure biological processes as they occur in living organisms, tissues and cells," says Kay. Kay's goal is to assemble a critical mass of investigators who will seek ways to study gene expression and protein activity in intact living cells. Richard Rorty, University Professor of the Humanities, will receive $308,120 over three years to establish a visiting lecturer program on the topic of `theory' in the social sciences and humanities. Visitors will lecture and participate in symposia designed to encourage interdisciplinary discussion among U.Va. faculty and students. Janet Herman, associate professor of environmental sciences and director of U.Va.'s Program of Interdisciplinary Research in Contaminant Hydrogeology (PIRCH), was awarded $322,435 over three years for interdisciplinary education and research in quantitative contaminant hydrogeology. "Groundwater contamination is clearly an urgent technical issue in our society," says Herman. The PIRCH faculty take an interdisciplinary approach to the subject, with the goals of understanding the fundamental technical issues of groundwater contamination and producing competent professionals who can address these issues from many vantage points, she adds. Since 1989, PIRCH has trained 28 M.S. and seven Ph.D. students. There are currently 38 students pursuing advanced degrees in the program. PIRCH faculty have also directed 52 independent research projects by undergraduates since 1989. Herman Shugart Jr., W.W. Corcoran Professor of Environmental Sciences, will receive $705,662 over three years to establish a Global Environmental Change Program. "This program will build on the existing strong U.Va. research in this area to study large-scale dynamics of the earth's surface and to develop, test, and apply mathematical models that simulate terrestrial responses to environmental change," says Shugart. The new program will consolidate the activities of faculty conducting research and teaching into an interdisciplinary undergraduate and graduate curriculum in large-scale environmental change, Shugart added. The group intends to develop and test a dynamic global vegetation model capable of predicting changes in the terrestrial surface. Giorgio Carta, associate professor of chemical engineering, will use $470,538 to begin a program in environmentally conscious chemical manufacturing (ECCM). "This program emphasizes pollution prevention, rather than waste treatment or environmental restoration, and has broad applications for industries that produce chemicals, drugs, paper, textiles, and plastics -- all of which are strongly represented in the economy of the Commonwealth," says Carta. The ECCM program will conduct fundamental research leading to new technologies needed to prevent pollution in chemical processing. The teaching aspect of the program will give chemical engineers an in-depth knowledge of environmental issues, Carta notes. James McCarthy, W. L. Lyons Brown Professor of Physics, will receive $561,056 over three years to direct a grant titled "The Fundamental Structure of the Neutron and Proton." Everything in the universe is made up of three atomic particles: electrons, protons, and neutrons, explains McCarthy. While electrons are fundamental -- they have no size and thus no underlying structure -- neutrons and protons may have more fundamental properties of size, mass, charge, and spin, which combine in various ways to make up their physical properties, McCarthy adds. Until 1987 the spin of the combined neutron and proton (called the nucleon) was thought to be a well- understood phenomenon, in which three quarks contributed to the overall spin of the particle. However, experiments in that year indicated that only a small amount of the proton's total spin is carried by quarks. Recent studies, including one proposed by U.Va. physicists, confirmed the 1987 findings. "One of the outstanding problems in particle physics is to understand the structure and origins of the nucleon's spin. This program will permit Virginia to build the essential equipment for the next generation of experiments to help resolve this challenging question. The graduate and undergraduate students involved in this program will be doing world-class basic research, and this is crucial to the education of superior and enthusiastic scientists," remarked McCarthy. Thomas Gallagher, Jesse W. Beams Professor of Physics, will receive $622,100 over three years with the goal of building a laser capable of probing and controlling chemical reactions. Laser pulses of extremely short duration (10-13 second, a femtosecond) can be used to take `snapshots' of a chemical reaction as it happens, explains Gallagher. Similarly, with sequenced pulses it may be possible to control the results of a reaction. "To realize our goals we must address many questions ranging from basic issues in chemical physics, such as how molecules interact with intense laser pulses, to those of immediate practical importance, such as how heat is transferred from a surface on a femtosecond time scale," says Gallagher. "An attractive feature of the program is that processes with commercial potential can be transferred to the free electron laser now under construction at the Continuous Electron Accelerator Facility in Newport News," he adds. Physics professor S. Joseph Poon and material science engineering professor Gary Shiflet are among the six-member team that will receive $799,876 over three years for a program in the science and technology of metallic glasses and nanocrystalline materials. This three-component program will capitalize on the pioneering work of Poon and Shiflet and colleagues, who discovered `glassy' metals in 1988. The glassy aluminum alloy is three times as strong as aluminum metal, but just as light as aluminum. Researchers will develop a fundamental understanding needed to synthesize metallic glasses with superior properties. General Motors will seek ways to use these new alloys in the transportation industry. The instructional goals, say the U.Va. researchers, are to provide broad involvement of graduate and undergraduate students in the full range of projects, from the stage of discovery and development to that of manufacturing and commercialization. ### June 9, 1995 REPORTERS AND EDITORS For more information, contact: Brian Duling (804) 924-5092 James Brookeman (804) 924-2596 Steve Kay (804) 982-5479 Richard Rorty (804) 924-4052 Janet Herman (804) 924-0553 Herman Shugart Jr. (804) 924-7642 Giorgio Carta (804) 924-6281 James McCarthy (804) 924-6783 Thomas Gallagher (804) 924-6817 S. Joseph Poon (804) 924-6792 Gary Shiflet (804) 982-5653